Zané Lombard, Lecturer (Bioinformatics)

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Research Interests

Analysis & management of high-throughput biological data, specifically GWAS and next-generation sequencing data.

Genetic factors influencing body composition in Africans.

Developmental origins of adult health and disease.

Postgraduate Students

Current students:

Ms Venesa Pillay. PhD Project: Identification of Genetic Markers of Obesity Risk in a South African Black Population.

Ms Shatadi Masemola. PhD Project: Epigenetic modification at imprinted loci following alcohol exposure during prenatal development.

Ms Liesl Hendry. MSc Project: Genetics of pain sensitivity associated with and susceptibility to the development of painful antiretroviral toxic neuropathy in HIV-positive individuals of Black African ancestry.

Past students:

Mr Andrew May. MSc Project: Investigating genetic factors influencing bone health in the black South African population.
Ms Punita Pitamber. MSc Project: Methylation profiling of paternally imprinted loci in male gametes following alcohol exposure.
Ms Sanam Patel. MSc Project: Effect of alcohol on global and locus specific DNA methylation in spermatozoa: implications for fetal alcohol spectrum disorders (FASD).

My Publications

Lombard Z, Crowther NJ, van der Merwe L, Pitamber P, Norris SA, Ramsay M. Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study. BMJ Open. 2012 May 21;2(3).

Pitamber PN, Lombard Z, Ramsay M. No Evidence for a Parent-of-Origin Specific Differentially Methylated Region Linked to RASGRF1. Front Genet. 2012;3:41.

Wadley AL, Lombard Z, Cherry CL, Price P, Kamerman PR. Analysis of a Previously Identified "Pain-Protective" Haplotype and Individual Polymorphisms in the GCH1 Gene in Africans With HIV-Associated Sensory Neuropathy: A Genetic Association Study. J Acquir Immune Defic Syndr. 2012 May 1;60(1):20-23.

Dandara C, Lombard Z, Du Plooy I, McLellan T, Norris SA, Ramsay M. Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity. Pharmacogenomics. 2011 Dec;12(12):1663-70.

Lombard Z, Park C, Makova KD, Ramsay M. A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis. Biol Direct. 2011;6:30

Ramsay M, Greenberg T, Lombard Z, Labrum R, Lubbe S, Aron S, Marais AS, Terry S, Bercovitch L, Viljoen D. Spectrum of genetic variation at the ABCC6 locus in South Africans: Pseudoxanthoma elasticum patients and healthy individuals. J Dermatol Sci. 2009 Jun;54(3):198-204.

Lombard Z, Tiffin N, Hofmann O, Bajic VB, Hide W, Ramsay M. Computational selection and prioritization of candidate genes for fetal alcohol syndrome. BMC Genomics. 2007 Oct 25;8:389.

Lombard Z, Dalton DL, Venter PA, Williams RC, Bornman L. Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa. Hum Immunol. 2006 Aug;67(8):643-54.

Lombard Z, Brune AE, Hoal EG, Babb C, Van Helden PD, Epplen JT, Bornman L. HLA class II disease associations in southern Africa. Tissue Antigens. 2006 Feb;67(2):97-110.

Student Opportunities

None at the moment. Check back here again soon!